Valley Fever can lead to respiratory issues, including dry cough and fatigue, and may cause severe complications in individuals with underlying health conditions. Those most at risk include older adults, pregnant women, and people with compromised immune systems due to conditions like cancer, HIV, or autoimmune diseases. Pets and livestock are also vulnerable, with symptoms such as breathing difficulties in dogs and skin infections in cats. The disease is not transmissible between humans or animals, but the health and economic impacts on affected individuals and communities can be significant, particularly in agricultural regions like the San Joaquin Valley.